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"ROW2’s RouteDesign service has given us many Novel Route ideas for our target molecules. The diverse route ideas recommended in RouteDesign reports also act as excellent stimuli to our own thought process. I must add that ROW2 team is very responsive and follow strict security norms. We are using RouteDesign service satisfactorily for the past 3 years."
-- Director Technology, Process R&D Dept, One of the top 10 global pharmaceutical companies.
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"ROW2's RouteDesign report gave us novel synthetic routes suitable for commercial scale that we had not considered before, and therefore, added to our team's knowledge. We would definitely use this service again."
-- Head of Process Research, a leading Pharma company, Germany
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"The three-molecule trial was a success. As a matter of fact, we are practicing some of the chemistry from two of the trial RouteDesigns in our laboratories today."
-- Head Science and Technology,A leading custom synthesis company, Switzerland
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RouteDesign is a
fully integrated service providing novel route(s) to a company's target
molecule. The route(s) developed through a RouteDesign
project use practical chemistries in a non-obvious manner to give commercially
scalable route(s) that have not been previously disclosed in patents
and literature. Additionally, RouteDesign
provides fully validated contact information for suppliers of commercially
produced intermediates and starting materials.
RouteDesign can add value
to:
- Small and Large Pharmaceutical companies
- Biotechnology companies working on small molecules
- Chemical companies developing their own products
How is RouteDesign developed?
The following process is used when completing
a RouteDesign project:
- Extensive review of the literature to present all published routes
to the target compound and its intermediates.
- Searching in ChemSpire® - Our scientists
leverage the commercial route knowledge in our application ChemSpire®
along with our proprietary searching techniques based on synthetic analogy.
- Generation of leads
- Leads are then fleshed out using CAS and our searches
- Leads are dropped or further pursued
- Syntheses are back integrated to commercially available starting
materials
- Based on these routes, ROW2
sourcing specialists validate key contact information for the relevant
suppliers of commercially produced intermediates and starting materials
- Quality Control
- Final RouteDesign Report is delivered to the client
The ROW2
teams follow a rigorous process when working on RouteDesign
projects. However, upon request from the client, ROW2 can involve chemists
from the client company in the early stages (through interim meetings) and leverage their lab experience in finalizing the report.
A typical RouteDesign report
includes:
- Executive Summary
- Compound Overview
- Literature Routes Review
- Practicality Analysis of the Literature Routes
- Commercially Viable Routes
- Supplier Details
- Bibliography
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Key Features
- ROW2
scientists combine their expertise and industrial experience with the
commercial route knowledge and non-obvious results delivered by our
revolutionary searches in our application ChemSpire®
to design commercially scalable and previously undisclosed route(s)
to your compound.
- All chemistry is based on analogies to
chemistry practiced commercially today, so it has a higher probability
to scale than only literature-based paper chemistry.
- All routes are back integrated to commercially
available starting materials. Based on the routes developed, ROW2
sourcing specialists provide fully validated contact details for suppliers
of commercially produced starting materials and intermediates.
RouteDesign Benefits
RouteDesign can benefit the following organizations:
| Large
Pharmaceutical companies |
Small
Pharmaceutical & Biotech companies |
- Delivers scalable and previously undisclosed syntheses
- Helps better evaluate various synthetic options
- Facilitates meeting tight project deadlines
- Allows for early selection of a commercial process reducing
time and cost of development quantities
- Allows the strengthening and broadening of your patent position
- Yields more cost efficient route(s)
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Same benefits as large pharmaceutical companies, along with:
- Powerful extension of your R&D team
- Helps increase your licensing package value
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Click
here to obtain more information | Read
Frequently Asked Questions (FAQs)
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